ChemBioScreen
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PLATEFORMES


Plateforme de criblage iPP BMYscreen

BMYscreenMise à jour le 10/06/2016



Responsable


S. Taouji

Thématique principale


Modulataurs d'interactions protéine-protéine

Techniques spécifiques


AlphaScreen, criblages cellulaires, autres

Systemes de détection


Lecteurs Envision et Cytation 3

Equipements particuliers


2 plateaux Robotique sous hotte à flux laminaire

Taille de la chimiothèque


1000 à 5000

Affiliation


INSERM Institut Bergonié Ubx

Brevets / Publications / Communications


1) Taouji S, Dahan S, Bossé R, Chevet E. Current Screens Based on the AlphaScreen Technology for Deciphering Cell Signalling Pathways. Curr Genomics. 2009 Apr;10(2):93-101.
2) Bouchecareilh M, Caruso ME, Roby P, Parent S, Rouleau N, Taouji S, Pluquet O, Bossé R, Moenner M, Chevet E. AlphaScreen-based characterization of the bifunctional kinase/RNase IRE1alpha: a novel and atypical drug target. J Biomol Screen. 2010 Apr;15(4):406-17.
3) Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.
4) Bouchecareilh M, Higa A, Fribourg S, Moenner M, Chevet E. IRE1alpha kinase-derived active peptides modulate IRE1alpha activity and protect cells from Endoplasmic Reticulum stress. FASEB Journal, 2011 Sep;25(9):3115-29.
5) Platonova N, Miquel G, Regenfuss B, Taouji S, Cursiefen C, Chevet E, Bikfalvi A. Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Blood. 2013 Feb 14;121(7):1229-37.
6) Bernard SC, Simpson N, Join-Lambert O, Federici C, Laran-Chich MP, Maïssa N, Bouzinba-Ségard H, Morand PC, Chretien F, Taouji S, Chevet E, Janel S, Lafont F, Coureuil M, Segura A, Niedergang F, Marullo S, Couraud PO, Nassif X, Bourdoulous S. Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization. Nat Med. 2014 Jul;20(7):725-31.
7) Dausse E, Taouji S, Evade L, Di Primo C, Chevet E*, Toulme JJ*. HAPIscreen, a method for high-throughput aptamer identification. J Nanobiotechnology. 2011 Jun 3;9(1):25. *corresponding authors.
8) Taouji S, Dausse E, Evadé L, Di Primo C, Toulmé JJ, Chevet E. Advances in binder identification and characterisation: the case of oligonucleotide aptamers. N Biotechnol. 2012 Jun 15;29(5):550-4.
9) Bideaud-Meynard A, Arma D, Taouji S, Laguerre M, Dessolin J, Rosenbaum J, Chevet E*, Moreau V*. A novel small-molecule screening strategy identifies mitoxantrone as a RhoGTPase inhibitor. Biochem J., 2013 Feb 15;450(1):55-62. *corresponding authors.
10) Taouji S, Higa A, Delom F, Palcy S, Mahon FX, Pasquet JM, Bosse R, Segui B, Chevet E. Phosphorylation of Serine Palmitoyl Transferase Long Chain-1 (SPTLC1) on Tyrosine 164 inhibits its activity and promotes cell survival. J Biol Chem. 2013 Jun 14;288(24):17190-201.
11) Pilati C, Letouzé E, Nault JC, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G, Mallet M, Taouji S, Balabaud C, Terris B, Canal F, Paradis V, Scoazec JY, de Muret A, Guettier C, Bioulac-Sage P, Chevet E, Calvo F, Zucman-Rossi J. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell. 2014 Apr 14;25(4):428-41.