• Institut Pasteur, Unité de Chimie et Biocatalyse
• 28 Rue du Dr Roux
• 75724 Paris cedex 15
• Tél. 01 45 68 83 81
• Fax 01 45 68 84 04
• Contact : helene.munier-lehmann@pasteur.fr
• Site internet : http://research.pasteur.fr/en/team/group-helene-munier-lehmann/

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Directeur d’équipe

Hélène Munier-Lehmann

Laboratoire de rattachement

Unité de Chimie et Biocatalyse

Directeur du laboratoire

Sylvie Pochet

Affiliation

Institut Pasteur et CNRS UMR3523

Thèmes principaux

Maladies infectieuses
Enzymes du métabolisme des nucléotides

Personnes associées

• Helynck Olivier
• Munier-Lehmann Hélène

Plateformes associées

• Criblage Biologique et Chimiothèques

Brevets / Publications / Communications

Publications (2015-2019) :

1.         Alexandre, T., Lupan, A., Helynck, O., Vichier-Guerre, S., Dugué, L., Gelin, M., Haouz, A., Labesse, G., and Munier-Lehmann, H. (2019) First-in-class allosteric inhibitors of bacterial IMPDHs. Eur. J. Med. Chem. 167, 124-132

2.         Thieulent, C. J., Hue, E. S., Fortier, C. I., Dallemagne, P., Zientara, S., Munier-Lehmann, H., Hans, A., Fortier, G. D., Pitel, P. H., Vidalain, P. O., and Pronost, S. L. (2019) Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay. Virology 526, 105-116

3.         Harigua-Souiai, E., Abdelkrim, Y. Z., Bassoumi-Jamoussi, I., Zakraoui, O., Bouvier, G., Essafi-Benkhadir, K., Banroques, J., Desdouits, N., Munier-Lehmann, H., Barhoumi, M., Tanner, N. K., Nilges, M., Blondel, A., and Guizani, I. (2018) Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic initiation factor 4A. PLoS neglected tropical diseases 12, e0006160

4.         Laskaris, P., Vicentefranqueira, R., Helynck, O., Jouvion, G., Calera, J. A., du Merle, L., Suzenet, F., Buron, F., de Sousa, R. A., Mansuy, D., Cavaillon, J. M., Latge, J. P., Munier-Lehmann, H., and Ibrahim-Granet, O. (2018) A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism. Antimicrob Agents Chemother 62, e02510-02517

5.         Song, L., Merceron, R., Gracia, B., Quintana, A. L., Risseeuw, M. D. P., Hulpia, F., Cos, P., Ainsa, J. A., Munier-Lehmann, H., Savvides, S. N., and Van Calenbergh, S. (2018) Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J Med Chem 61, 2753-2775

6.         Suthagar, K., Jiao, W., Munier-Lehmann, H., and Fairbanks, A. J. (2018) Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydrate Research 457, 32-40

7.         Buchieri, M. V., Cimino, M., Rebollo-Ramirez, S., Beauvineau, C., Cascioferro, A., Favre-Rochex, S., Helynck, O., Naud-Martin, D., Larrouy-Maumus, G., Munier-Lehmann, H., and Gicquel, B. (2017) Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis. J. Med. Chem. 60, 7425-7433

8.         Dabo, S., Maillard, P., Collados Rodriguez, M., Hansen, M. D., Mazouz, S., Bigot, D. J., Tible, M., Janvier, G., Helynck, O., Cassonnet, P., Jacob, Y., Bellalou, J., Gatignol, A., Patel, R. C., Hugon, J., Munier-Lehmann, H., and Meurs, E. F. (2017) Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Scientific Reports 7, 16129

9.         Khiar, S., Lucas-Hourani, M., Nisole, S., Smith, N., Helynck, O., Bourgine, M., Ruffie, C., Herbeuval, J. P., Munier-Lehmann, H., Tangy, F., and Vidalain, P. O. (2017) Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Scientific Reports 7, 2561

10.       Koseki, Y., Kanetaka, H., Tsunosaki, J., Munier-Lehmann, H., and Aoki, S. (2017) Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium. Int. J. Mycobacteriol. 6, 61-69

11.       Lucas-Hourani, M., Dauzonne, D., Munier-Lehmann, H., Khiar, S., Nisole, S., Dairou, J., Helynck, O., Afonso, P. V., Tangy, F., and Vidalain, P. O. (2017) Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response. Antimicrobial Agents and Chemotherapy 61, e00383-00317

12.       Adamska, A., Rumijowska-Galewicz, A., Ruszczynska, A., Studzinska, M., Jablonska, A., Paradowska, E., Bulska, E., Munier-Lehmann, H., Dziadek, J., Lesnikowski, Z. J., and Olejniczak, A. B. (2016) Anti-mycobacterial activity of thymine derivatives bearing boron clusters. Eur. J. Med. Chem. 121, 71-81

13.       Grandin, C., Hourani, M. L., Janin, Y. L., Dauzonne, D., Munier-Lehmann, H., Paturet, A., Taborik, F., Vabret, A., Contamin, H., Tangy, F., and Vidalain, P. O. (2016) Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors. Antiviral Research 125, 58-62

14.       Laskaris, P., Atrouni, A., Calera, J. A., d'Enfert, C., Munier-Lehmann, H., Cavaillon, J. M., Latge, J. P., and Ibrahim-Granet, O. (2016) Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin. Antimicrobial Agents and Chemotherapy 60, 5631-5639

15.       Petrella, S., Aubry, A., Janvier, G., Coutant, E. P., Cartier, A., T.-H., D., Bonhomme, F. J., Motreff, L., Pissis, C., Bizet, C., Clermont, D., Begaud, E., Retailleau, P., Munier-Lehmann, H., Capton, E., Mayer, C., and Janin, Y. L. (2016) Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors. Canadian Journal of Chemistry 94, 240-250

16.       Raj, S., Krishnan, K., Askew, D. S., Helynck, O., Suzanne, P., Lesnard, A., Rault, S., Zeidler, U., d'Enfert, C., Latge, J. P., Munier-Lehmann, H., and Saveanu, C. (2016) The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components. Antimicrobial Agents and Chemotherapy 60, 1438-1449

17.       Song, L., Risseeuw, M. D., Froeyen, M., Karalic, I., Goeman, J., Cappoen, D., Van der Eycken, J., Cos, P., Munier-Lehmann, H., and Van Calenbergh, S. (2016) Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents. Bioorg Med Chem 24, 5172-5182

18.       Alexandre, T., Raynal, B., and Munier-Lehmann, H. (2015) Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties PloS one 10, e0116578

19.       Labesse, G., Alexandre, T., Gelin, M., Haouz, A., and Munier-Lehmann, H. (2015) Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation. Acta Crystallogr D Biol Crystallogr 71, 1890-1899

20.       Lucas-Hourani, M., Munier-Lehmann, H., El Mazouni, F., Malmquist, N. A., Harpon, J., Coutant, E. P., Guillou, S., Helynck, O., Noel, A., Scherf, A., Phillips, M. A., Tangy, F., Vidalain, P. O., and Janin, Y. L. (2015) Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). J. Med. Chem. 58, 5579-5598

21.       Munier-Lehmann, H., Lucas-Hourani, M., Guillou, S., Helynck, O., Zanghi, G., Noel, A., Tangy, F., Vidalain, P. O., and Janin, Y. L. (2015) Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). J. Med. Chem. 58, 860-877

22.       Vidalain, P. O., Lucas-Hourani, M., Helynck, O., Tangy, F., and Munier-Lehmann, H. (2015) [Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening]. Medecine sciences : M/S 31, 98-104